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Body composition changes from AOD-9604 or CJC-1295 + Ipamorelin typically require eight to twelve weeks for initial metabolic shifts and three to six months for measurable composition changes

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(ii) GxG (Gene x Gene) interaction, wherein the loss of two genes leads to a fitness phenotype that is not the simple additive sum of two single KOs, and (iii) GxGxE (Gene x Gene x Environment) interaction, wherein the impact of the pairwise genetic interaction is dependent on the metabolic state